List of publications

2016

Caljon G, De Muylder G, Durnez L, Jennes W, Vanaerschot M, Dujardin JC (2016). Alice in microbes’ land: adaptations and counter-adaptations of vector borne parasitic protozoa and their hosts. FEMS Microbiology Reviews, 40(5):664-85. doi: 10.1093/femsre/fuw018.

Caljon G, Van Reet N, De Trez C, Vermeersch M, Pérez-Morga D, Van Den Abbeele J (2016). The dermis as a delivery site of Trypanosoma brucei for tsetse flies. Plos Pathogens 12(7):e1005744.doi: 10.1371/journal.ppat.1005744.

Cnops J, Kauffmann F, De Trez C, Baltz T, Keirsse J, Radwanska M, Muraille E, Magez S (2016) Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection. Parasite Immunology 38(10):642-7. doi: 10.1111/pim.12344.

Cuypers B, Lecordier L, Meehan CJ, Van den Broeck F, Imamura H, Büscher P, Dujardin JC, Laukens K, Schnaufer A, Dewar C, Lewis M, Balmer O, Azurago T, Kyei-Faried S, Ohene AS, Duah B, Homiah P, Mensah EK, Anleah F, Franco JR, Pays E, Deborggraeve S (2016). Apolipoprotein L1 variant associated with increased susceptibility to trypanosome infection. mBio 7, e02198-15. doi: 10.1128/mBio.02198-15.

Imamura H, Downing T, Van den Broeck F, Sanders M, Rijal S, Sundar S, Mannaert A, Vanaerschot M, Berg M, De Muylder G, Dumetz F, Cuypers B, Maes I, Decuypere S, Rai K, Uranw S, Bhattarai N, Khanal B, Prajapati V, Stark O, Schönian G, De Koning H, Settimo L, Vanhollebeke B, Roy S, Ostyn B, Boelaert M, Maes L, Berriman M, Dujardin JC, Cotton JA (2016). Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent. Elife, e12613. doi: 10.7554/eLife.12613.

Kauffmann F, Dumetz F, Hendrickx S, Muraille E, Dujardin JC, Maes L, Magez S, De Trez C (2016). In vivo characterization of two additional Leishmania donovani strains using the murine and hamster model. Parasite Immunology 38(5):290-302. doi: 10.1111/pim.12316.

Odongo S, Sterckx YG, Stijlemans B, Pillay D, Baltz T, Muyldermans S, Magez S (2016) An anti-proteome nanobody library approach yields a specific immunoassay for Trypanosoma congolense diagnosis targeting glycosomal aldolase. PLoS Neglected Tropical Diseases 10(2):e0004420. doi: 10.1371/journal.pntd.0004420.

Scott CL, Zheng F, De Baetselier P, Martens L, Saeys Y, De Prijck S, Lippens S, Abels C, Schoonooghe S, Raes G, Devoogdt N, Lambrecht BN, Beschin A, Guilliams M (2016). Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells. Nature Communications 7:10321. doi: 10.1038/ncomms10321.

Sparkes A, De Baetselier P, Roelants K, De Trez C, Magez S, Van Ginderachter JA, Raes G, Bucala R, Stijlemans B (2016).  The non-mammalian MIF superfamily. Immunobiology pii: S0171-2985(16)30413-2. doi: 10.1016/j.imbio.2016.10.006.

Stijlemans B, Caljon G, Van Den Abbeele J, Van Ginderachter JA, Magez S, De Trez C (2016). Immune evasion strategies of Trypanosoma brucei within the mammalian host: progression to pathogenicity. Frontiers in Immunology 7:233. doi: 10.3389/fimmu.2016.00233.

Stijlemans B, Brys L, Korf H, Bieniasz-Krzywiec P, Sparkes A, Vansintjan L, Leng L, Vanbekbergen N, Mazzone M, Caljon G, Van Den Abbeele J, Odongo S, De Trez C, Magez S, Van Ginderachter JA, Beschin A, Bucala R, De Baetselier P (2016). MIF-Mediated hemodilution promotes pathogenic anemia in experimental African trypanosomosis. PLoS Pathogens 12(9):e1005862. doi: 10.1371/journal.ppat.1005862.

Trindade S, Rijo-Ferreira F, Carvalho T, Pinto-Neves D, Guegan F, Aresta-Branco F, Bento F, Young SA, Pinto A, Van Den Abbeele J, Ribeiro RM, Dias S, Smith TK, Figueiredo LM (2016). Trypanosoma brucei parasites occupy and functionally adapt to the adipose tissue in mice. Cell Host Microbe 19(6):837-48. doi: 10.1016/j.chom.2016.05.002.

Uzureau S, Coquerelle C, Uzureau P, Vermeiren C, Pilotte L, Van Acker A, Acolty V, Vanhollebeke B, Van den Eynde B, Moser M, Pays E (2016). Apolipoproteins L control cell death triggered by TLR3/TRIF signaling in dendritic cells. European Journal of Immunology 46(8):1854-66. doi: 10.1002/eji.201546252.

Zheng F, Sparkes A, De Baetselier P, Schoonooghe S, Stijlemans B, Muyldermans S, Flamand V, Van Ginderachter J, Devoogdt N, Raes G, Beschin A (2016) Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis. Molecular Imaging and Biology, Jun 23. [Epub ahead of print]

2015

Arias JL, Unciti-Broceta JD, Maceira J, Del Castillo T, Hernández-Quero J, Magez S, Soriano M, García-Salcedo JA (2015). Nanobody conjugated PLGA nanoparticles for active targeting of African Trypanosomiasis. Journal of Controlled Release 197:190-8. doi: 10.1016/j.jconrel.2014.11.002

Bachmaier S, Witztum R, Tsigankov P, Koren R, Boshart M, Zilberstein D (2015). Protein kinase A signaling during bidirectional axenic differentiation in Leishmania. International Journal for  Parasitology 46: 75-82. doi: 10.1016/j.ijpara.2015.09.003.

Berg M, García-Hernández R, Cuypers B, Vanaerschot M, Manzano JI, Poveda JA, Ferragut JA, Castanys S, Dujardin JC, Gamarro F (2015). Experimental resistance to drug combinations in Leishmania donovani: metabolic and phenotypic adaptations. Antimicrobial Agents and Chemotherapy 59(4):2242-55. doi: 10.1128/AAC.04231-14.

Besnard AG, Guabiraba R, Niedbala W, Palomo J, Reverchon F, Shaw TN, Couper KN, Ryffel B, Liew FY (2015). IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T Cells. PLoS Pathogens 11(2):e1004607. doi: 10.1371/journal.ppat.1004607.

Burbulis IE, Yamaguchi K, Nikolskaia OV, Prigge ST, Magez S, Bisser S, Reller ME, Grab DJ (2015). Detection of pathogen-specific antibodies by loop-mediated isothermal amplification. Clinical and Vaccine Immunology 22(4):374-80. doi: 10.1128/CVI.00811-14.

Caljon G, Hussain S, Vermeiren L, Van Den Abbeele J (2015). Description of a nanobody-based competitive immunoassay to detect tsetse fly exposure. PLoS Neglected Tropical Diseases 9(2):e0003456. doi: 10.1371/journal.pntd.0003456.

Cnops J, Bockstal V, De Trez C, Miquel MC, Radwanska M, Magez S (2015). Curative drug treatment of trypanosomosis leads to the restoration of B-cell lymphopoiesis and splenic B-cell compartments. Parasite Immunology 37(9):485-91. doi: 10.1111/pim.12209.

Cnops J, De Trez C, Bulté D, Radwanska M, Ryffel B, Magez S (2015). IFNg is a crucial driver of B cell disappearance in experimental African trypanosomosis. Parasite Immunology 37(9):479-84. doi: 10.1111/pim.12208.

Cnops J, De Trez C, Stijlemans B, Keirsse J, Kauffmann F, Barkhuizen M, Keeton R, Boon L, Brombacher F, Magez S (2015). NK-, NKT- and CD8-derived IFNγ drives myeloid cell activation and erythrophagocytosis, resulting in rrypanosomosis-associated acute anemia. PLoS Pathogens 12;11(6):e1004964. doi: 10.1371/journal.ppat.1004964.

Cnops J, Magez S, De Trez C (2015). Escape mechanisms of African trypanosomes: why trypanosomosis is keeping us awake. Parasitology 142(3):417-27. doi: 10.1017/S0031182014001838.

De Trez C, Katsandegwaza B, Caljon G, Magez S (2015). Experimental African trypanosome infection by needle passage or natural tsetse fly challenge thwarts the development of collagen-induced arthritis in DBA/1 prone mice via an impairment of antigen specific B cell autoantibody titers. PLoS One 10(6):e0130431. doi: 10.1371/journal.pone.0130431.

François A, Gombault A, Villeret B, Alsaleh G, Fanny M, Gasse P, Adam SM, Crestani B, Sibilia J, Schneider P, Bahram S, Quesniaux V, Ryffel B, Wachsmann D, Gottenberg JE, Couillin I (2015). B cell activating factor is central to bleomycin- and IL-17-mediated experimental pulmonary fibrosis. Journal of Autoimmunity 56:1-11. doi: 10.1016/j.jaut.2014.08.003.

Haubrich BA, Singha UK, Miller MB, Nes CR, Anyatonwu H, Lecordier L, Patkar P, Leaver DJ, Villalta F, Vanhollebeke B, Chaudhuri M, Nes WD (2015). Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth. Journal of Lipid Research 56(2):331-41. doi: 10.1194/jlr.M054643.

Haynes CL, Ameloot P, Remaut H, Callewaert N, Sterckx YG, Magez S (2015). Production, purification and crystallization of a trans-sialidase from Trypanosoma vivax. Acta Crystallographica Section F Structural Biology and Crystallization Communications 71 (5):577-85. doi: 10.1107/S2053230X15002496.

Lecordier L, Uzureau P, Tebabi P, Brauner J, Benghiat FS, Vanhollebeke B, Pays E (2015). Adaptation of Trypanosoma rhodesiense to hypohaptoglobinaemic serum requires transcription of the APOL1 resistance gene in a RNA polymerase I locus. Molecular Microbiology 97(3):397-407. doi: 10.1111/mmi.13036.

Limou S, Nelson GW, Lecordier L, An P, O’hUigin CS, David VA, Binns-Roemer EA, Guiblet WM, Oleksyk TK, Pays E, Kopp JB, Winkler CA (2015). Sequencing rare and common APOL1 coding variants to determine kidney disease risk. Kidney International 88(4):754-63. doi:10.1038/ki.2015.151.

Liu G, Xu J, Wu H, Sun D, Zhang X, Zhu X, Magez S, Shi M (2015). IL-27 signaling is crucial for survival of mice infected with African trypanosomes via preventing lethal effects of CD4+ T cells and IFN-γ. PLoS Pathogens 29;11(7):e1005065. doi: 10.1371/journal.ppat.1005065.

Lun ZR, Wen YZ, Uzureau P, Lecordier L, Lai DH, Lan YG, Desquesnes M, Geng GQ, Yang TB, Zhou WL, Jannin JG, Simarro PP, Truc P, Vincendeau P, Pays E (2015). Resistance to normal human serum reveals Trypanosoma lewisi as an underestimated human pathogen. Molecular Biochemical Parasitology 199 (1-2):58-61. doi: 10.1016/j.molbiopara.2015.03.007.

Morias Y, Abels C, Laoui D, Van Overmeire E, Guilliams M, Schouppe E, Tacke F, deVries CJ, De Baetselier P, Beschin A (2015). Ly6C-monocytes regulate parasite-induced liver inflammation by inducing the differentiation of pathogenic Ly6C+ monocytes into macrophages. PLoS Pathogens 11(5):e1004873. doi: 10.1371/journal.ppat.1004873.

Mukherjee B, Paul J, Mukherjee S, Mukhopadhyay R, Das S, Naskar K, Sundar S, Dujardin JC, Saha B, Roy S (2015). Antimony-resistant Leishmania donovani exploits miR-466i to deactivate host MyD88 for regulating IL-10/IL-12 levels during early hours of infection. Journal of Immunology 195(6):2731-42. doi: 10.4049/jimmunol.1402585.

Palomo J, Reverchon F, Piotet J, Besnard AG, Couturier-Maillard A, Maillet I, Tefit M, Erard F, Mazier D, Ryffel B, Quesniaux VF (2015). Critical role of IL-33 receptor ST2 in experimental cerebral malaria development. European Journal of Immunology,  45(5):1354-65. doi: 10.1002/eji.201445206.

Shameer S, Logan-Klumpler FJ, Vinson F, Cottret L, Merlet B, Achcar F, Boshart M, Berriman M, Breitling R, Bringaud F, Butikofer P, Cattanach AM, Bannerman-Chukualim B, Creek DJ, Crouch K, de Koning HP, Denise H, Ebikeme C, Fairlamb AH, Ferguson MA, Ginger ML, Hertz-Fowler C, Kerkhoven EJ, Maser P, Michels PA, Nayak A, Nes DW, Nolan DP, Olsen C, Silva-Franco F, Smith TK, Taylor MC, Tielens AG, Urbaniak MD, van Hellemond JJ, Vincent IM, Wilkinson SR, Wyllie S, Opperdoes FR, Barrett MP, Jourdan F (2015). TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research 43: D637-644. doi: 10.1093/nar/gku944

Stijlemans B, Beschin A, Magez S, Van Ginderachter JA, De Baetselier P (2015). Iron homeostasis and Trypanosoma brucei associated immunopathogenicity development: A battle/quest for iron. Biomed Research International 2015:819389. doi: 10.1155/2015/819389.

Stijlemans B, Cnops J, Naniima P, Vaast A, Bockstal V, De Baetselier P, Magez S (2015). Development of a pHrodo-based assay for the assessment of in vitro and in vivo erythrophagocytosis during experimental trypanosomosis. PLoS Neglected Tropical Diseases 9(3):e0003561.;doi: 10.1371/journal.pntd.0003561.

Vanwalleghem G, Fontaine F, Lecordier L, Tebabi P, Klewe K, Nolan DP, Yamaryo-Botté Y, Botté C, Kremer A, Burkard GS, Rassow J, Roditi I, Pérez-Morga D, Pays E (2015). Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1. Nature Communications 6:8078. doi: 10.1038/ncomms9078.

Unciti-Broceta JD, Arias JL, Maceira J, Soriano M, Ortiz-González M, Hernández-Quero J, Muñóz-Torres M, de Koning HP, Magez S, Garcia-Salcedo JA (2015). Specific cell targeting therapy bypasses drug resistance mechanisms in African trypanosomiasis. PLoS Pathogens 25;11(6):e1004942. doi: 10.1371/journal.ppat.1004942.

2014

Allmann S, Mazet M, Ziebart N, Bouyssou G, Fouillen L, Dupuy JW, Bonneu M, Moreau P, Bringaud F, Boshart M (2014). Triacylglycerol Storage in Lipid Droplets in Procyclic Trypanosoma brucei. PLoS One 9: e114628.

Beschin A, Van Den Abbeele J, De Baetselier P, Pays E (2014). African trypanosome control in the insect vector and mammalian host. Trends in Parasitology 30 (11):538-47; doi: 10.1016/j.pt.2014.08.006.

Caljon G, Duguma R, De Deken R, Schauvliege S, Gasthuys F, Duchateau L, Van Den Abbeele J (2014). Serological Responses and Biomarker Evaluation in Mice and Pigs Exposed to Tsetse Fly Bites. PLoS Neglected Tropical Diseases 8(5): e2911.

Dujardin JC, Mannaert A, Durrant C, Cotton J (2014). Mosaic aneuploidy in Leishmania: the perspective of whole genome sequencing. Trends in Parasitology 30: 554-5.

Guha R, Das S, Ghosh J, Sundar S, Dujardin JC,  Roy S (2014). Antimony resistant Leishmania donovani but not sensitive ones drives greater frequency of potent T-regulatory cells upon interaction with human PBMCs: Role of IL-10 and TGF-β in early immune response. PLOS Neglected Tropical Diseases 8: e2995.

International Glossina Genome Initiative* (2014).Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis. Science 344 (6182):380-6. * includes Caljon G. and Van Den Abbeele J. as co-authors

Kassem A, Pays E, Vanhamme L (2014). Transcription is initiated on silent variantsurface glycoprotein expression sites despite monoallelic expression in Trypanosoma brucei. Proceedings of the National  Academy of  Sciences USA 111(24):8943-8.

La Greca F, Haynes C, Stijlemans B, De Trez C, Magez S (2014). Antibody-mediated control of Trypanosoma vivax infection fails in the absence of tumour necrosis factor. Parasite Immunology 36(6):271-6.

Lecordier L, Uzureau P, Tebabi P, Pérez-Morga D, Nolan D, Schumann Burkard G, Roditi I, Pays E (2014) Identification of Trypanosoma brucei components involved in trypanolysis by normal human serum. Molecular Microbiology 94(3):625-36.

Mukherjee S, Mukherjee B, Mukhopadhyay R, Naskar K, Sundar S, Dujardin JC, Roy  S (2014). Imipramine exploits Histone Deacetylase 11 to increase IL-12/IL-10 ratio in macrophages infected with antimony resistant Leishmania donovani and clears organ parasite in experimental infection. Journal of Immunology  193: 4083-94.

Obishakin E, de Trez C, Magez S (2014). Chronic Trypanosoma congolense infections in mice cause a sustained disruption of the B-cell homeostasis in the bone marrow and spleen. Parasite Immunology 36(5):187-98.

Obishakin E, Stijlemans B, Santi-Rocca J, Vandenberghe I, Devreese B, Muyldermans S, Bastin P, Magez S (2014) Generation of a nanobody targeting the paraflagellar rod protein of trypanosomes. PLoS One 9(12):e115893.

Palomo J, Marchiol T, Piotet J, Fauconnier L, Robinet M, Reverchon F, Le Bert M, Togbe D, Buijs-Offerman R, Stolarczyk M, Quesniaux VF, Scholte BJ, Ryffel B (2014) Role of IL-1β in experimental cystic fibrosis upon P. aeruginosa infection. PLoS One 12;9(12):e114884.

Pays E, Vanhollebeke B, Uzureau P, Lecordier L, Pérez-Morga D (2014). The molecular arms race between African trypanosomes and humans. Nature Reviews Microbiology 12(8):575-84.

Rabolli V, Badissi A, Devosse R, Uwambayinema F, Yakoub Y, Palmai-Pallag M, Lebrun A, De Gussem V, Couillin I, Ryffel B, Marbaix E, Lison D, Huaux F (2014). The alarmin IL-1 is a master cytokine in acute lung inflammation induced by silica micro- and nanoparticles. Particle and Fibre Toxicology 13;11(1):69.

Stijlemans B, Leng L, Brys L, Sparkes A, Vansintjan L, Caljon G, Raes G, Van Den Abbeele J, Van Ginderachter JA, Beschin A, Bucala R, De Baetselier P (2014). MIF contributes to Trypanosoma brucei associated immunopathogenicity development. PLoS Pathogens 10(9):e1004414.

Vanaerschot M, Dumetz F, Roy S, Ponte-Sucre A, Arevalo J, Dujardin JC (2014). Treatment failure in leishmaniasis: drug-resistance or another (epi-) phenotype? Expert Review of Anti- Infective Therapy 12: 937-46.

Van den Bergh R, Van Ginderachter JA, Schouppe E, Desimmie BA, Hailu A, De Baetselier P, van Griensven J (2014). Visceral leishmaniasis relapse in HIV patients–a role for myeloid-derived suppressor cells? PLoS Neglected Tropical Diseases 11;8(9):e3132.

2013

Allmann S, Morand P, Ebikeme C, Gales L, Biran M, Hubert J, Brennand A, Mazet M, Franconi JM, Michels PA, Portais JC, Boshart M, Bringaud F (2013). Cytosolic NADPH homeostasis in glucose-starved procyclic Trypanosoma brucei  Relies on malic enzyme and the pentose phosphate pathway fed by gluconeogenic flux. The Journal of Biological Chemistry 288: 18494-505.

Berg M, Mannaert A, Vanaerschot M, Van der Auwera G, Dujardin JC (2013). (Post-)Genomic approaches to tackle drug resistance in Leishmania. Parasitology 140(12):1492-505.

Berg M, Vanaerschot M, Jankevics A, Cuypers B, Maes I, Mukherjee S, Khanal B, Rijal S, Roy S, Opperdoes F, Breitling R, Dujardin JC (2013). Metabolic adaptations of Leishmania donovani in relation to differentiation, drug resistance, and drug pressure.  Molecular Microbiology 90(2):428-42.

Beschin A, De Baetselier P, Van Ginderachter JA (2013). Contribution of myeloid cell subsets to liver fibrosis in parasite infection. Journal of Pathology 229(2):186-97.

Brasseur A, Rotureau B,  Vermeersch M, Blisnick T, Salmon D, Bastin P, Pays E, Vanhamme L,  Pérez-Morga D (2013). Trypanosoma brucei FKBP12 differentially controls motility and cytokinesis in procyclic and bloodstream forms. Eukaryotic Cell 12: 168-181.

Caljon G, De Vooght L, Van Den Abbeele J (2013). Options for the delivery of anti-pathogen molecules in arthropod vectors. Journal of Invertebrate Pathology 112 Suppl:S75-82.

De Muylder G, Daulouède S, Lecordier L, Uzureau P, Morias Y, Van Den Abbeele J, Caljon G, Hérin M, Holzmuller P, Semballa S, Courtois P, Vanhamme L, Stijlemans B, De Baetselier P, Barrett MP, Barlow JL, McKenzie AN, Barron L, Wynn TA, Beschin A, Vincendeau P, Pays E (2013).  A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity. PLoS Pathogens 9(10):e1003731.

Dujardin JC, Decuypere S (2013). Epidemiology of leishmaniasis in the time of drug resistance.  In: Drug Resistance in Leishmania Parasites. Consequences, Molecular Mechanism and Possible Treatments. Edited by Alicia Ponte-Sucre, Maritza Padron-Nieves and Emilia Diaz. Spinger-Verlag, Wienen. pp 65-83.

Guha R, Das S, Ghosh J, Naskar K, Mandala A, Sundar S, Dujardin JC, Roy S (2013). Heterologous priming-boosting with DNA and vaccinia virus expressing kinetoplastid membrane protein-11 induces potent cellular immune response and confers protection against infection with antimony resistant and sensitive strains of Leishmania (Leishmania) donovani. Vaccine  31(15):1905-15.

Rotureau B, Van Den Abbeele J (2013). Through the dark continent: African trypanosome development in the tsetse fly.  Frontiers in Cellular and Infection Microbiology  3:53.

Uzureau P, Uzureau S, Lecordier L, Fontaine F, Tebabi P, Homblé F, Grélard A, Zhendre V, Nolan DP, Lins L, Crowet JM, Pays A, Felu C, Poelvoorde P, Vanhollebeke B, Moestrup SK, Lyngsø J, Pedersen JS, Mottram JC, Dufourc EJ, Pérez-Morga D, Pays E (2013). Mechanism of Trypanosoma brucei gambiense resistance to human serum.  Nature 501(7467):430-4.

Vanaerschot M, Decuypere S, Berg M, Roy S, Dujardin JC (2013). Drug-resistant microorganisms with a higher fitness – can medicines boost pathogens?  Critical Reviews in Microbiology 39(4):384-94.

Vanaerschot M, Huijben S, Van den Broeck F, Dujardin JC (2013). Drug resistance in vectorborne parasites: multiple actors and scenarios for an evolutionary arms race.

FEMS Microbiology Reviews  Jul 1. [Epub ahead of print]

Van Den Abbeele J, Bourtzis K, Weiss B, Cordón-Rosales C, Miller W,  Abdalla A,  Parker A  (2013). Enhancing Tsetse fly refractoriness to Trypanosome infection – A new IAEA Coordinated Research Project. Journal of Invertebrate Pathology 112 Suppl:S75-82.

2012

Breitling R, Bakker B, Barrett M, Decuypere S, Dujardin JC (2012). Metabolomic systems biology of protozoan parasites. In: Genetics meets Metabolomics: from Experiment to Systems Biology. Ed. Karsten Suhre. Springer, pp.73-84.

Caljon G, De Ridder K, Stijlemans B, Coosemans M, Magez S, De Baetselier P, Van Den Abbeele J (2012). Tsetse salivary gland proteins 1 and 2 are high affinity nucleic acid binding proteins with residual nuclease activity. PLoS One 7(10):e47233.

Caljon G, Stijlemans B, Saerens D, Van Den Abbeele J, Muyldermans S, Magez S, De Baetselier P (2012). Affinity is an important determinant of the anti-trypanosome activity of nanobodies. PLoS Neglected Tropical Diseases 6(11):e1902.

Caljon G, Caveliers V, Lahoutte T, Stijlemans B, Ghassabeh GH, Van Den Abbeele J, Smolders I, De Baetselier P, Michotte Y, Muyldermans S, Magez S, Clinckers R (2012). Using microdialysis to analyse the passage of monovalent nanobodies through the blood-brain barrier. British Journal of Pharmacology 165(7):2341-53.

De Vooght L, Caljon G, Stijlemans B, De Baetselier P, Coosemans M, Van Den Abbeele J (2012). Expression and extracellular release of a functional anti-trypanosome  Nanobody® in Sodalis glossinidius, a bacterial symbiont of the tsetse fly. Microbial Cell Factories 11:e23.

Hendrickx S, Inocêncio da Luz RA, Bhandari V, Lonchamp J, Salotra P, Carter K, Sundar S, Rijal S, Dujardin JC, Cos P, Maes L (2012). Experimental induction of paromomycin resistance in antimony-resistant strains of L. donovani: outcome dependent on selection protocol. PLoS Neglected Tropical Diseases 6(5):e1664.

Mannaert A, Downing T, Imamura H, Dujardin JC (2012). Novel adaptive mechanisms in pathogens: universal aneuploidy in Leishmania. Trends in Parasitology 28(9):370-6.

Millerioux Y, Morand P, Biran M, Mazet M, Moreau P, Wargnies M, Ebikeme C, Deramchia K, Gales L, Portais JC, Boshart M, Franconi JM, Bringaud F (2012). ATP synthesis-coupled and -uncoupled acetate production from acetyl-CoA by mitochondrial acetate:succinate CoA-transferase and acetyl-CoA thioesterase in Trypanosoma. The Journal of Biological Chemistry 287: 17186-97.

Mukherjee B, Mukhopadhyay R, Bannerjee B, Chowdhury S, Mukherjee S, Naskar K, Shankar Alam U, Chakravorty D, Sundar S, Dujardin JC, Roy S (2012). Antimony resistant Leishmania donovani upregulates multi drug resistant protein1 in IL-10 dependent manner by exploiting the Toll2 immune receptor. Proceeding of the National Society of Sciences – USA, 110(7):E575-82.

Mukherjee S, Mukherjee B, Mukhopadhyay R, Naskar K, Sundar D, Dujardin JC, Roy S (2012) Imipramine is an Orally Active Drug Against both Antimony Sensitive and Resistant Leishmania donovani Clinical Isolates in Experimental Infection. PLoS Neglected Tropical Diseases 6(12):e1987.

Raes G, De Baetselier P, Van Ginderachter JA (2012). Plasticity of monocytes, macrophages and dendritic cells is reflected in distinct organs and tissues. Immunobiology 217(12):1223-4.

Raes G, De Baetselier P, Van Ginderachter JA (2012). Clinical and fundamental aspects of monocyte, macrophage and dendritic cell plasticity. European  Journal of Immunology, 42(1):13-6.

Salmon D, Bachmaier S, Krumbholz C, Kador M, Grossmann J, Uzureau P, Pays E*,Boshart, M* (2012). Cytokinesis of Trypanosoma brucei bloodstream forms depends on expression of adenylyl cyclases of the ESAG4 or ESAG4-like sub-family. Molecular Microbiology 84: 225-42. (* equal senior authors)

Salmon D, Vanwalleghem G, Morias Y, Denoeud J, Krumbholtz K, Lhommé F, Bachmaier S, Kador M, Gossmann J, Braga Stehling Dias F, De Muylder G, Uzureau P, Magez  S, Moser M, De Baetselier P, Van Den Abbeele J, Beschin A, Boshart M, Pays E (2012). Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host. Science 337: 463-66.

Schmieder A, Schledzewski K, Michel J, Schönhaar K, Morias Y, Bosschaerts T, Van den Bossche J, Dorny P, Sauer A, Sticht C, Géraud C, Waibler Z, Beschin A, Goerdt S (2012). The CD20 homolog Ms4a8a integrates pro- and anti-inflammatory signals in novel M2-like macrophages and is expressed in parasite infection. European Journal of Immunology 42(11):2971-82.

Van den Bossche J, Laoui D, Morias Y, Movahedi K, Raes G, De Baetselier P, Van Ginderachter JA (2012). Claudin-1, claudin-2 and claudin-11 genes differentially associate with distinct types of anti-inflammatory macrophages in vitro and with parasite- and tumour-elicited macrophages in vivo. Scandinavian Journal of Immunology 75(6):588-98.

Van den Bossche J, Malissen B, Mantovani A, De Baetselier P, Van Ginderachter JA (2012). Regulation and function of the E-cadherin/catenin complex in cells of the monocyte-macrophage lineage and DCs. Blood 119(7):1623-33.